Hello–sorry for the delay.
As of now, we’re not seeing liquidity issues with Binance.us, but it’s something to monitor. But the most volume (best liquidity) is in BTC/USDT there.
In terms of fees, if you’re not trading a large account, the Coinbase Pro fees can be a killer for active traders. As you move up their volume stack, you’ll get more favorable rates.
We do also have the calculator here which can give some good approximations: https://crypto-ml.com/trading-bot-roi-calculator/